Monday, April 30, 2012

Study: Heavy teens have trouble managing diabetes - Aiken Standard

  PUBLISHED: 5/1/2012 12:32 AM |  Print |  E-mail | Viewed: times

LOS ANGELES (AP) -- New research sends a stark warning to overweight teens: If you develop diabetes, you'll have a very tough time keeping it under control.

A major study, released Sunday, tested several ways to manage blood sugar in teens newly diagnosed with diabetes and found that nearly half of them failed within a few years and 1 in 5 suffered serious complications. The results spell trouble for a nation facing rising rates of "diabesity" - Type 2 diabetes brought on by obesity.

The federally funded study is the largest look yet at how to treat diabetes in teens. Earlier studies mostly have been in adults, and most diabetes drugs aren't even approved for youths. The message is clear: Prevention is everything.

"Don't get diabetes in the first place," said Dr. Phil Zeitler of the University of Colorado Denver, one of the study leaders.

A third of American children and teens are overweight or obese. They are at higher risk of developing Type 2 diabetes, in which the body can't make enough insulin or use what it does make to process sugar from food. Until the obesity epidemic, doctors rarely saw children with Type 2 diabetes. The more common kind of diabetes in children is Type 1, which used to be called juvenile diabetes.

Doctors usually start Type 2 treatment with metformin, a pill to lower blood sugar. If it still can't be controlled, other drugs and daily insulin shots may be needed. The longer blood sugar runs rampant, the greater the risk of suffering vision loss, nerve damage, kidney failure, limb amputation - even heart attacks and strokes.

The goal of the study was simple: What's the best way for teens to keep diabetes in check?

The study involved 699 overweight and obese teens recently diagnosed with diabetes. All had their blood sugar normalized with metformin, then were given one of three treatments to try to maintain that control: metformin alone, metformin plus diet and exercise counseling, or metformin plus a second drug, Avandia.

After nearly four years, half in the metformin group failed to maintain blood sugar control. The odds were a little better for the group that took two drugs but not much different for those in the lifestyle group.

Even so, Zeitler said doctors would not recommend this combination drug therapy because Avandia has been linked to higher risk of heart attacks in adults. Those risks became known after this study had started.

Another study leader from Children's Hospital Los Angeles, Dr. Mitchell Geffner, agreed that Avandia can't be recommended for teens, but said the study makes clear they will need more than metformin to control their disease.

"A single pill or single approach is not going to get the job done," he said.

Among all the teens in the study, 1 in 5 had a serious complication such as very high blood sugar, usually landing them in the hospital.

The results were published online Sunday by the New England Journal of Medicine and presented at a pediatric meeting in Boston. The National Institutes of Health funded the study and drug companies donated the medications.

The "discouraging" results point to the need to create "a healthier 'eat less, move more"' culture to help avoid obesity that contributes to diabetes, Dr. David Allen of the University of Wisconsin School of Medicine and Public Health wrote in an accompanying editorial.

Judith Garcia still struggles to manage her diabetes with metformin and insulin years after taking part in the study at Children's Hospital Los Angeles. She has to remember to watch her diet and set aside time to exercise.

"Trust me, I'm working on it," said the 19-year-old who lives in Commerce, Calif.

Kelsi Amer, a 14-year-old high school freshman from Patriot, Ind., knows how tough it is to keep her blood sugar from skyrocketing. Diagnosed at age 12, she takes metformin and gives herself insulin shots before school and at bedtime.

There are times when she has to miss class because she has to prick her finger to check her blood sugar or go with her mother to Cincinnati Children's Hospital Medical Center for check-ups.

"I try real hard and all of a sudden, I'm back to high blood sugar" levels, said Kelsi, who was not part of the research.

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Online:

New England Journal of Medicine: http://www.nejm.org

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Are Some Teenagers Wired for Addiction? - Wall Street Journal (blog)

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In the largest imaging study of the adolescent brain ever conducted â€" involving 1,896 14-year-olds â€" scientists report in Nature Neuroscience that some teenagers may be more inclined to experiment with drugs and alcohol, simply because their brains work differently, making them more impulsive.

Moreover, different brain networks appear to be involved in the self-control problems of substance abuse among teenagers than those associated with attention deficit hyperactivity disorder, or ADHD, even though both problems stem, in part, from a failure to inhibit behavior, the scientists report.

“The behavior might look the same but there may be different brain regions contributing to that behavior,” says neuroimaging expert Dr. Robert Whelan at the University of Vermont, who was the study’s lead author. The study is part of a larger project funded by the European Union that is conducting a systematic neural, genetic and behavioral assessment of teenagers in Ireland, England, France, and Germany.

Whelan and his colleagues used functional magnetic resonance imaging, which tracks the changes in blood flow between neurons associated with mental activity. They monitored brain responses as the teenagers moved one hand in response to a stream of commands, a widely used research protocol called the “stop-signal task” that is much like a game of Simon Says.  Periodically â€" and unpredictably â€" the volunteers would be ordered to stop moving their hands. The researchers identified seven neural networks active when the teenagers could stop themselves and six other brain circuits active when they could not.

Generally, the researchers found that the adolescents with ADHD symptoms, which is the most common neurodevelopmental psychiatric disorder, and those who had used drugs or alcohol had an equally hard time handling the task.

Among those with a history of alcohol, cigarettes, and illegal drug use, however, they found that the impulse control problem was associated with diminished activity in a brain region called the orbitofrontal cortex. The researchers found an entirely separate set of impulse-control networks connected with the symptoms of ADHD, which were distinct from those associated with adolescent substance abuse.

“Our study lends credence to the idea that ADHD and substance abuse are not intrinsically linked together,” Whelan tells the Health Blog. “There appear to be different regions associated with different kinds of impulsivity.”

Gene find raises hopes of new pancreatic cancer treatment - Times of India

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LONDON: Scientists have identified a gene that slows the spread of pancreatic cancer tumours, a finding they say could lead to new targeted treatments for the deadliest disease.

An international team of researchers found that the gene, called USP9x, is switched off in some pancreatic cancer cells mice. But when turned on, the gene stops cancerous cells from dividing uncontrollably, the researchers said.

The gene is not mutated, but other proteins and chemicals become stuck to it and turn the gene off.

Drugs having the potential to turn the gene back on can help stop the spread of the fifth most deadly cancer that affects nearly 8,000 people in the UK alone every year.

Prof David Tuveson, of the Cancer Research UK Cambridge Research Institute, said: "We suspected that the fault wasn't in the genetic code at all, but in the chemical tags on the surface of the DNA that switch genes on and off, and by running more lab tests we were able to confirm this.

"Drugs which strip away these tags are already showing promise in lung cancer and this study suggests they could also be effective," Prof Tuveson was quoted as saying by the BBC.

Dr David Adams, from the Wellcome Trust Sanger Institute, said: "This study strengthens our emerging understanding that we must also look into the biology of cells to identify all the genes that play a role in cancer."

They argue that up to 15 per cent of pancreatic cancers could be down the turning this one gene off.

"These results raise the possibility that a class of promising new cancer drugs may be effective at treating some pancreatic cancers," added Dr Julie Sharp, Cancer Research UK's senior science information manager.

The study is published in the journal Nature.

Type 2 diabetes surges among children and teens -- and key treatment for ... - CBS News

There was more bad news Monday about this country's diabetes epidemic. Some 26 million Americans suffer from Type 2 diabetes, most of them adults. But the number of young people with the disease is growing fast. And now researchers have found that a key medication for treating it in grown-ups often fails in teenagers, as CBS News medical correspondent Dr. Jon LaPook reports.

Twenty-one-year-old Sara Chernov checks her blood sugar every day, one of many changes in her life since being diagnosed with Type 2 diabetes at age 16.

"It's definitely troubling for anybody dealing with a chronic disease to keep yourself on track, especially when you go through the phases of denial and understanding that this is a chronic disease," Chernov said.

Since 1980, obesity in children has almost tripled to more than 12 million. And that, says, Dr. Robin Goland, who helped run the study, has fueled a rise in Type 2 diabetes in young people.

"Historically, childhood diabetes has not been Type 2 diabetes, so very little is known about the right way to both prevent it and to treat it," Goland said.

Type 2 diabetes is the disease in which the body can't make enough insulin to process the sugar it takes in from food. Formerly, it was considered rare to encounter Type 2 diabetes in children, as opposed to Type 1 diabetes (once known as "juvenile diabetes").

Medications that control blood sugar lower the risk of patients developing complications such as poor circulation, blindness, and kidney disease. But the most commonly prescribed drug in adults, metformin, failed more than half the time in the young patients in the study.

"We can prevent them from getting diabetes, that would be far preferable than being in the position of treating it," Goland said.

That's been the goal in New York City, which has been waging an aggressive anti-obesity campaign for years, taking measures such as posting calorie counts on menus and banning sugary drinks from public schools. Health Commissioner Dr. Tom Farley says willpower alone is not enough.

"We're going to have to try to engineer physical activities back into our daily lives ... get PE more back into schools," he said. "Second, we're going to have increase access to healthy foods like fruits and vegetables and reduce the availability and promotion of the calorie-dense snack foods that make it so easy for us to consume too many calories."

And little is being done in our nation's high schools to help. Only 17 percent of students get the recommended one hour of moderately vigorous physical activity a day.

LaPook said that preventative programs like the ones in New York City are an excellent investment, even if they entail some up-front cost. The total cost of obesity plus diabetes in this country each year is $340 billion.

US sees sharp rise in newborns with opiate withdrawal - BBC News

Crying baby (file image)Newborns showing withdrawal symptoms often require treatment to wean them off the drug

The number of babies born in the US showing symptoms of opiate withdrawal increased threefold in the 10 years up to 2009, a medical study has found.

The research, published in the Journal of the American Medical Association, said one in every 1,000 newborns was affected in 2009.

The number of pregnant women testing positive for illegal or legal opiates increased fivefold in the same period.

The report says abuse of prescription painkillers is partly to blame.

The study, the first of its kind in the US, was based on records from more than 4,000 hospitals across the country.

It found that in 2009, about 13,500 babies were born with withdrawal symptoms - roughly one every hour.

Public health burden

Not all babies born to women who used opiates during pregnancy showed the symptoms, the report said.

But those that did were often born earlier and smaller, suffered seizures, restlessness, breathing problems or difficulty feeding and often required treatment with the opiate-replacement drug methadone to help wean them off their dependency.

"They appear uncomfortable, sometimes they breathe a little faster. They're scratching their faces," said Dr Stephen Patrick of the University of Michigan, who worked on the study.

The babies were kept in hospital for an average of 16 days, compared to three for health babies.

As most were born to mothers who were entitled to financial help with their medical costs, the study said this was placing a serious burden on health budgets.

The researchers said many pregnant women were legitimately taking pain-relieving opiates on prescription, but warned that more must be done to find ways of protecting unborn babies from powerful drugs.

Dr Patrick said the findings were "part of a bigger call to the fact that opiates are becoming a big problem in this country".

An editorial in the journal accompanying the study said that while such opiate medications provide "superior pain control" they have been "overprescribed, diverted and sold illegally, creating a new opiate addiction pathway and a public health burden for maternal and child health".

In 2011, the Centers for Disease Control and Prevention (CDC) warned that painkiller abuse in the US had reached "epidemic proportions".

It said overdoses of pain relievers cause more deaths than heroin and cocaine combined.

Judge: Texas can't ban Planned Parenthood from health program - msnbc.com

NBC's Andrea Mitchell talks with Cecile Richards, president of Planned Parenthood, about the latest piece of legislation out of Texas that would block funding for the state's Planned Parenthood centers.

By msnbc.com staff and news services

A federal judge on Monday blocked a Texas law that would have excluded Planned Parenthood from participating in the state's women's health program.

U.S. District Judge Lee Yeakel ruled Monday there is sufficient evidence the state law is unconstitutional. He imposed a temporary injunction against enforcing the law until he can hear full arguments.


The law passed last year by the Republican-controlled Legislature forbids state agencies from providing funds to an organization affiliated with abortion providers. It was set to go into effect on Tuesday.

In response, eight Planned Parenthood clinics that don't provide abortions sued the state. The clinics say the law unconstitutionally restricts their freedom of speech and association.

In granting the preliminary injunction, Planned Parenthood can continue to serve women, and getting reimbursed by the state, according to the Austin Statesman.

"The court is particularly influenced by the potential for immediate loss of access to necessary medical services by several thousand Texas women," Yeakel said in a 24-page ruling.

Texas officials have said that if the state is forced to include Planned Parenthood, they likely will shut down the program that serves basic health care and contraception to 130,000 poor women.

The Associated Press and Reuters contributed to this report.

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Efforts spread to cut family planning services - USA TODAY

The Downtown Austin Planned Parenthood Clinic, a center that has been servicing low-income women for four decades, is now scrambling to keep services free.

The Downtown Austin Planned Parenthood Clinic, a center that has been servicing low-income women for four decades, is now scrambling to keep services free.

By Joel Salcido, for USA TODAY

AUSTIN â€" Emily Howell's frequent trips to the Planned Parenthood clinic on East Seventh Street here have less to do with preventing unwanted pregnancies and more about keeping cancer from creeping back into her body.

  • Emily Howell, 30, from Austin relies on the services of the Downtown Austin Planned Parenthood Clinic.

    Joel Salcido, for USA TODAY

    Emily Howell, 30, from Austin relies on the services of the Downtown Austin Planned Parenthood Clinic.

Joel Salcido, for USA TODAY

Emily Howell, 30, from Austin relies on the services of the Downtown Austin Planned Parenthood Clinic.

Eleven years ago, Howell beat a malignant tumor in her stomach. Today, she visits the clinic for free cervical exams, breast screenings, STD testing and birth control pills â€" none of which she could afford.

"It's a huge burden off me," says Howell, 30, an environmental sciences student at Austin Community College. "Pregnancy and cervical cancer are the last things I need to worry about."

Those services, however, may soon vanish in an ongoing struggle between conservative Texas lawmakers and women's groups here to curtail funding for Planned Parenthood and other clinics affiliated with abortion providers.

Last year, the Republican-controlled Legislature slashed $74 million from the Family Planning Program, forcing 155 clinics to close. The clinics offered services such as cervical exams, breast exams and free birth control but, under state law, could not provide abortions.

In another move, lawmakers passed a law essentially shutting out Planned Parenthood from funding through the state's Medicaid Women's Health Program. Together, the two moves would cut services to more than 300,000 low-income women annually across Texas, according to the Texas Legislative Budget Board.

On Monday, a U.S. District judge ruled that Texas cannot exclude Planned Parenthood from the Women's Health Program. The ruling is a temporary injunction and a final ruling is expected later.

"The ruling today is great news for Texas women," says Sarah Wheat, interim chief executive officer of Planned Parenthood of the Texas Capital Region. "It's a clear message that politics doesn't belong in women's health care."

Gov. Rick Perry's administration, which supports the cuts, appealed the ruling. "Texas has a long history of protecting life, and we are confident in Attorney General (Greg) Abbott's appeal to defend the will of Texans and our state law, which prohibits taxpayer funds from supporting abortion providers and affiliates in the Women's Health Program," Catherine Frazier, Perry's press secretary, said in a statement.

By Joel Salcido, for USA TODAY

Tewabech Aychiluhem, a clinical assistant, prepares a Depo-Provera injection, a long-term hormonal contraceptive.

'Death by a thousand cuts'

Supporters of the cuts say they are part of a belt-tightening effort to deflate the state's $27 billion deficit â€" with a special focus on cutting funds for abortion-related groups.

"We went after not just the abortionists but those who did the health checks, screenings and would refer people to the abortionists," says state Rep. Wayne Christian, a Republican, who voted for the cuts. "Citizens in Texas do not want to support abortions with their tax dollars."

Women's rights advocates decry the cuts as an attack on women's reproductive rights. The moves will lead to more unwanted pregnancies and potentially more abortions, especially in a state that ranks third in the USA in teen pregnancies and has the highest percentage of uninsured residents in the country, says Regina Rogoff, chief executive officer of People's Community Clinic, which lost $526,000 of its operating budget to the cuts. "It's a concerted effort to set back the rights of women," she says. "It's death by a thousand cuts."

By Joel Salcido, for USA TODAY

Medical assistant Letty Montelongo performs several pregnancy tests.

The Texas cuts are the latest in a nationwide effort by states to defund family planning services, says Elizabeth Nash, an analyst with the Guttmacher Institute, a New York-based policy and research center that advocates reproductive health rights for women.

Last year, lawmakers across the USA introduced more than 1,100 reproductive-health and rights-related provisions, up from 950 the year before, Nash says. "We have never seen so many attacks on family planning as we did last year," she says.

Recent examples:

•New Hampshire lawmakers last year voted to cut more than $1 million from the state family planning budget, says Jennifer Frizzell, senior policy adviser with the Planned Parenthood of Northern New England.

• Two Tennessee Planned Parenthood groups filed a federal lawsuit against the state in February for redirecting more than $150,000 in federal grant money away from the non-profit clinics, according to court documents.

• Arizona lawmakers are considering a bill that would prohibit the state from contracting with any group that performs abortion or runs a facility where abortions are performed, according to the Center for Arizona Policy.

Affects low-income women

In Texas, one of the biggest casualties of the cuts was Planned Parenthood, which was forced to close 11 of its 76 clinics across the state, mostly in poorer areas, such as the Rio Grande Valley to the south, Wheat says. None of the closed clinics performed abortions.

Clinics in Austin and other large cities were able to stay open through last-minute fundraising, she says. But without new funding streams, the future of the clinics is uncertain. "We're literally in brand-new, uncharted waters," Wheat says.

Community Action Network, a group that serves low-income women in rural areas, was forced to close two of its four clinics in central Texas â€" an abrupt loss of services low-income women have relied on for four decades, executive director Carole Belver says.

"It's taken 45 years to build up the infrastructure we have in the state of Texas to provide health care services for low-income women," Belver says. "This is going to unravel all of it."

Erectile dysfunction drug Stendra approved by FDA - CBS News

(Credit: iStock)

(CBS News) A new erectile dysfunction drug that reportedly works in less than 15 minutes has just received approval from the U.S. Food and Drug Administration. On Friday the FDA approved Vivus Inc.'s Stendra to take as an "as-needed" pill for men.

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More than 30 million men in the U.S. are affected by erectile dysfunction (ED). Current ED drugs on the market include Pfizer Inc.'s Viagra, Eli Lilly's Cialis and GlaxoSmithKline and Bayer's drug Levitra.

The new drug Stendra, the brand name for avanafil, is the first new erectile dysfunction drug in a decade for this class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors.

"This approval expands the available treatment options to men experiencing erectile dysfunction, and enables patients, in consultation with their doctor, to choose the most appropriate treatment for their needs," Dr. Victoria Kusiak, deputy director of the Office of Drug Evaluation III in the FDA's Center for Drug Evaluation and Research, said in an FDA statement.

Similar to its counterparts, the drug works by helping increase blood flow to the penis. How does it stack up against the rest?

"This is potentially the fastest acting of the four," Dr. Wayne Hellstrom, professor of urology at Tulane University School of Medicine in New Orleans, told Reuters. Patients taking Stendra are recommended to take the drug 30 minutes before sexual activity but clinical trials have shown the drug works as fast as 15 minutes. Viagra may take an hour to start working, Reuters reported.

In clinical trials, 77 percent of men with general ED were able to get erections after taking Stendra, compared with 54 percent of men taking a placebo pill, WebMD reported. Stendra resulted in successful intercourse for 57 percent of men with general ED, compared with 27 percent of men on placebo.

According to the FDA, the most common side effects for men taking Stendra were headache, face redness, nasal congestion, cold-like symptoms, and back pain. In rare cases men may get an erection that does not go away after four hours - a condition known as priapism. If that happens, patients should seek immediate medical care, the FDA said.

As with other PDE5 inhibitors, Stendra should not be used by men who also take nitrates commonly used to treat chest pain, because the combination can cause a sudden drop in blood pressure.

WebMD has more on erectile dysfunction.


Study finds teens at risk of drug abuse have unique brain networks - Fox News

Differences in the networks of brain cells may explain why some teenagers are more susceptible to impulsive risk-taking behavior like smoking or experimenting with drugs, according to a new study.

The study, published in the journal Nature Neuroscience, sheds light on the question of whether certain brain patterns that are characteristic of drug users occur because of the drug use or are the cause of drug use.  

Using functional brain imaging of 1,896 14-year-olds, the researchers from the University of Vermont identified seven networks involved when impulses were successfully inhibited and six networks involved when inhibition failed.  The teenagers were asked to perform a repetitive task that involved pushing a button on a keyboard, and then asked to stop the act of pushing the button in mid-action. When teenagers were successful at stopping mid-act, the inhibitive networks would light up. Those teens with better inhibitory control were able to succeed at this task faster.

Researchers looked at activity in the "orbitofrontal cortex," a region of the brain associated with experimentation with alcohol, cigarettes and illegal drugs in early adolescence.  They found that activity in this region was reduced in those who misused any substance (alcohol, nicotine or illicit substances), even in those who only used alcohol one to four times in their life.  This strongly suggests, since one to four uses is unlikely to substantially impair brain functions, that the differences in brain networks were there before the drug use.

"These networks are not working as well for some kids as for others," said University of Vermont researcher Robert Whelan, a co-author of the study.  This makes them more impulsive, he said.

The study also found that separate neural networks are involved with the symptoms of attention deficit hyperactivity disorder (ADHD). These ADHD networks are distinct from those associated with early drug use.

This is an important finding because there has been some concern that having ADHD puts someone at risk for substance abuse. But this study shows that these similar impulse issues are regulated by different networks in the brain, suggesting that ADHD is not necessarily a full-blown risk for drug use as some other recent studies suggested.

Though adolescence is a time to push boundaries and take risks, for teens who are pre-wired to have poor impulse control, it may lead to dangerous or harmful behavior. Some studies have shown that early educational interventions focusing on improving cognitive control are effective in improving impulse control. For example, one type of training, called PATHS (Promoting Alternative Thinking Strategies) teaches children, when they get upset, to stop, take a deep breath, say what the problem is and how they feel, and construct an action plan. After this type of training, children had better inhibitory control.

Laurie Tarkan is an award-winning health journalist whose work appears in the New York Times, among other national magazines and websites. She has authored several health books, including "Perfect Hormone Balance for Fertility." Follow her on Twitter and Facebook.

Study: Teens brains' may predispose them to drug abuse, impulsive behavior - CBS News

(Credit: istockphoto)

(CBS News) Why do some teens turn to drugs while others don't? According to the new research, the answer may be found in newly discovered networks in teens' brains.

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For the largest imaging study of human brains ever conducted, researchers from the University of Vermont studied the brains of 1,896 14-year-olds with functional magnetic resonance imaging (fMRI) scans. During the scans, the teens were asked to perform a task that involved pressing a button on a keyboard and then having to keep themselves from pressing that button at an unpredictable cue. That task would require the brain to inhibit the act of pushing the button, which could be used to measure how impulsive a teen is.

The researchers found differences in these brain networks caused some teens to act more impulsively than others: teens who were able to stop the signal had the certain networks "light up" on the fMRI scan. Acting more impulsively raises a teen's risk for drug and alcohol experimentation, the researchers said.

"These networks are not working as well for some kids as for others," leading them to become more impulsive, Robert Whelan, a post-doctoral researcher at the University of Vermont, said in a university written statement.

When given the opportunity to smoke, drink or do drugs, a 14-year-old with a less functional impulse-regulating network will be more likely to say, "yeah, gimme, gimme, gimme!" study author Dr. Hugh Garavan, an associate professor of psychiatry at the University of Vermont, told LiveScience.

The researchers said this study solves a "chicken-or-egg" question of whether brain changes come before drug use or are caused from it. Their findings are published in the April 29 issue of Nature Neuroscience.

Differences in a different set of brain networks were also connected to symptoms were tied to another impulsivity-related condition, attention-deficit hyperactivity disorder (ADHD). ADHD is a disorder that causes problems with over-activity, inattention, impulsivity or a combination of all those factors beyond what's typical for a child's development.

In recent years research has suggested a link between ADHD and likelihood for substance abuse, but the new study suggests ADHD is not a full-blown risk for drug use since the problems are regulated by different networks.

"The take-home message is that impulsivity can be decomposed, broken down into different brain regions, and the functioning of one region is related to ADHD symptoms, while the functioning of other regions is related to drug use," said Garavan.

So what does it all mean?

The researchers said in the statement that a better understanding of brain networks that put some teens at high risk for drug abuse can aid public health by reducing the number of deaths among teens - which are often caused by preventable accidents caused by impulsive risky behaviors.


Number of US newborns with drug addictions triples - The Seattle Times

DETROIT â€" An increased reliance on prescription painkillers and the resulting addiction has now shown up in the most vulnerable patients â€" America's newborns, according to a report released Monday.

Addicted babies â€" many suffering from respiratory problems, low-birth weight and seizures â€" have nearly tripled in less than a decade.

That's one baby every hour in the U.S., according to the study in the Journal of the American Medical Association, said Dr. Stephen Patrick, lead author and doctor at the University of Michigan Medical Center's Neonatal Intensive Care Unit.

Meanwhile, the number of mothers using opiates has increased fivefold, according to the same study.

It's also a burden on public-health dollars â€" and a wake-up call about the need for better prevention, Patrick said.

Average costs to care for the babies suffering from neonatal abstinence syndrome, or NAS, skyrocketed from $39,400 to $53,400 between the same time period â€" 2000 to 2009, according to the study.

In addition to seizures and breathing problems, NAS is marked by low birth weight, irritability, muscle cramping, tremors, feeding problems, vomiting and watery stools.

"Generally babies are soothed by wrapping or holding or being fed," said Patrick. "Typically these babies can't be consoled."

Babies were in the hospital for an average of 16 days, and 78 percent were covered by Medicaid.

The source of their mother's addiction? The study doesn't address why the mothers were using drugs, nor did it explore what specific drugs they used â€" though NAS is most commonly linked to opiates, according to the study.

Dr. Carl Christensen, who runs the Eleanor Hutzel Recovery Center in Detroit, said he sees it all the time: Doctors who too easily prescribe painkillers, and patients who demand them.

The clinic treats more than 100 addicted moms-to-be a year, said Christensen, who is also an associate professor of obstetrics and gynecology at Wayne State University in Detroit.

Most women were prescribed Vicodin and OxyContin to manage pain from injury or disease, Christensen said.

"A lot of patients ... feel they don't have an addiction as long as they can get their prescription filled," he said. "A lot of them say 'I have pain and as long as I have pain I should be able to take medicine.' "

Addiction takes hold in as little as two weeks, he said, and women face the daunting task of detoxifying â€" a physical struggle, as withdrawal can lead to rapid pulse and breathing, high blood pressure, abdominal cramps, tremors, bone and muscle pain, vomiting, diarrhea, sleeplessness and depression.

The increase in use began more than a decade ago when doctors began to focus on pain and its management, said Dr. Philip Gilly, medical director at Henry Ford Health System's Maplegrove Center, which provides both in- and outpatient treatment.

Patrick said the specific treatment for these babies is unclear â€" precisely which babies should be treated, with what kind of drug, and what dosage. At the University of Michigan, they use methadone; another clinic uses morphine.

"You don't want to over treat it, and we don't have want under treat it," he said. "It's tricky. We need more research."

Doctors say newborns aren't really addicted â€" which connotes drug-seeking behavior that babies aren't capable of â€" but their bodies are dependent on methadone or other opiates because of their mothers' use during pregnancy.

Small methadone doses to wean them off these drugs is safer than cutting them off altogether, which can cause dangerous seizures and even death, said Dr. Mark Brown, chief of pediatrics at Eastern Maine Medical Center.

Texas Planned Parenthood Can Get Funds, Judge Rules - Wall Street Journal

AUSTIN, Texasâ€"A federal judge on Monday stopped Texas from preventing a health organization affiliated with abortion providers from receiving state funds. The state immediately appealed.

U.S. District Judge Lee Yeakel in Austin ruled there is sufficient evidence that a law banning Planned Parenthood from the state's Women's Health Program is unconstitutional. He imposed an injunction against enforcing it until he can hear full arguments. Texas Attorney General Greg Abbott appealed Judge Yeakel's decision to the 5th U.S. Circuit Court of Appeals, asking that it remove the injunction.

The law passed last year by the Republican-controlled Legislature forbids state agencies from providing funds to an organization affiliated with abortion providers. Eight Planned Parenthood clinics that don't provide abortions sued the state. The clinics say the law unconstitutionally restricts their freedom of speech and association.

The judge accepted Planned Parenthood's argument that banning the organization from the program would leave women without access to clinics for basic health services and check-ups.

"The court is particularly influenced by the potential for immediate loss of access to necessary medical services by several thousand Texas women," Judge Yeakel wrote in his ruling. "The record before the court at this juncture reflects uncertainty as to the continued viability of the Texas Women's Health Program."

Texas officials have said that if the state is forced to include Planned Parenthood, they will likely shut down the program that serves basic health care and contraception to 130,000 poor women. Judge Yeakel acknowledged that was a risk.

"The court observes that if the federal funds are phased out, Texas does not provide another source of funds, and the Women's Health Program terminates, the controversy now before the court may be of no consequence," he wrote.

The Women's Health Program was established to provide care for poor women who wouldn't otherwise qualify for Medicaid, the federal and state program that insures low-income and disabled people. It supplies cancer screenings, annual exams, and access to birth control.

Stephanie Goodman, spokeswoman for the state Department of Health and Human Services, said the agency will seek guidance from the Texas attorney general on next steps.

"We received the judge's order and will comply with the ruling, but we remain confident that federal law gives states the right to establish criteria for Medicaid providers," she said.

Patricio Gonzales, CEO of Planned Parenthood Association of Hidalgo County, called on Republican Gov. Rick Perry to stop trying to shut down Planned Parenthood in Texas.

"We call on Governor Perry and the state to put Texan women first and set aside any vendetta they may have against Planned Parenthood," Ms. Gonzales said. "No woman should ever have to fear being cut off from her doctor's care because of shortsighted political games."

The court's decision comes after the federal government cut off funding to Texas because of the state requirement. Federal officials said the rule violates federal law by restricting women from choosing the qualified medical provider of their choice.

Mr. Perry promised to make up for the lost federal funds. State health officials say maintaining the program was cheaper than allowing it to expire, because ending the program would result in a spike in unplanned pregnancies among poor women who rely on Medicaid, which is also funded by the state.

Judge Yeakel's decision is temporary. A final decision will come after he presides over a full trial. Whatever decision he reaches will likely be appealed.

Why Texas judge lifted ban on state funds for Planned Parenthood - Christian Science Monitor

US District Judge Lee Yeakel ruled Monday that a law banning Planned Parenthood from getting state health funds may be unconstitutional. The judge's injunction is temporary.

A federal judge on Monday stopped Texas from preventing Planned Parenthood from getting state funds through the Women's Health Program.

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US District Judge Lee Yeakel in Austin ruled there is sufficient evidence that a law banning Planned Parenthood from the program is unconstitutional. He imposed an injunction against enforcing it until he can hear full arguments.

The law passed last year by the Republican-controlled Legislature forbids state agencies from providing funds to an organization affiliated with abortion providers. Eight Planned Parenthood clinics that do not provide abortions sued the state. The clinics say the law unconstitutionally restricts their freedom of speech and association to qualify to take part in state health programs.

RECOMMENDED: Study says unsafe abortions on the rise

The judge accepted Planned Parenthood's argument that banning the organization from the program would leave women without access to clinics for basic health services and check-ups.

"The court is particularly influenced by the potential for immediate loss of access to necessary medical services by several thousand Texas women," Yeakel wrote in his ruling. "The record before the court at this juncture reflects uncertainty as to the continued viability of the Texas Women's Health Program."

Texas officials have said that if the state is forced to include Planned Parenthood, they will likely shut down the program that serves basic health care and contraception to 130,000 poor women. Yeakel acknowledged that was a risk.

"The court observes that if the federal funds are phased out, Texas does not provide another source of funds, and the Women's Health Program terminates, the controversy now before the court may be of no consequence," he wrote.

Patricio Gonzales, CEO of Planned Parenthood Association of Hidalgo County, called on Republican Gov. Rick Perry to stop trying to shut down Planned Parenthood in Texas.

"We call on Governor Perry and the state to put Texan women first and set aside any vendetta they may have against Planned Parenthood," Gonzales said. "No woman should ever have to fear being cut off from her doctor's care because of shortsighted political games."

The court's decision comes after the federal government cut off funding to Texas because of the state requirement. Federal officials said the rule violates federal law by restricting women from choosing the qualified medical provider of their choice.

Perry promised to make up for the lost federal funds. State health officials say maintaining the program was cheaper than allowing it to expire, because ending the program would result in a spike in unplanned pregnancies among poor women who rely on Medicaid, which is also funded by the state.

Yeakel's decision is temporary. A final decision will come after he presides over a full trial. Whatever decision he reaches will likely be appealed.

Copyright 2012 The Associated Press.

RECOMMENDED: Study says unsafe abortions on the rise

Type 2 Diabetes Is Tougher to Treat in Kids and Teens - TIME

Image Source / Getty Images

Image Source / Getty Images

Type 2 diabetes, the kind linked with obesity, progresses much faster and is harder to treat in children than in adults, according to the disappointing results of a new study that sought to determine the best treatment for the disease in obese teens.

The study, the largest to examine Type 2 diabetes treatment in youth, looked at the effectiveness of several methods to manage blood sugar in newly diagnosed teens aged 10 to 17. The researchers found that nearly half of all participants failed to maintain stable blood sugar over the four-year study, and 1 in 5 suffered serious complications as a result.

The findings are troubling for teens’ health since obesity and diabetes rates are increasing nationwide. Uncontrolled diabetes can increase the risk for serious health problems, including heart disease, vision loss, nerve problems, amputations and kidney failure.

(MORE: Mom’s Obesity, Diabetes Linked with Autism and Developmental Delays)

Type 2 diabetes â€" once referred to as adult-onset diabetes â€" was rarely seen among children before the 1990s. But as American children and teens started getting fatter, related cases of diabetes began to rise. Today, Type 2 diabetes is still uncommon in children (Type 1, or juvenile, diabetes affects more youths), but the disease continues to increase at an alarming rate: between 2002 and 2005, there were about 3,600 new cases of Type 2 diabetes in children and teens a year.

For the new study, released Sunday by the New England Journal of Medicine, researchers followed 699 overweight and obese teens who had been recently diagnosed with diabetes. Most of the participants were from low-income families; 40% were Hispanic, 33% black, 20% white, 6% American Indian and fewer than 2% were Asian.

All of the participants were started off on metformin, the standard oral medication for Type 2 diabetes, to normalize their blood sugar levels. They were then divided into three treatment groups to maintain blood sugar control. One group continued to use metformin alone; another used metformin along with an intensive diet, exercise and weight-loss program; the third used metformin plus another drug, rosiglitazone (Avandia).

(MORE: Q&A: Losing Weight Doesn’t Help Obese Girls Love Themselves â€" Can Parents?)

Failure rates were high for all three treatment groups. About half of the teens in the metformin group failed to keep their blood sugar down, 39% failed in the group using metformin plus Avandia, and 47% failed in the diet and exercise group.

“It’s frightening how severe this metabolic disease is in children,” study author Dr. David M. Nathan, director of the diabetes center at Massachusetts General Hospital, told the New York Times. “I fear that these children are going to become sick earlier in their lives than we’ve ever seen before

The authors could only speculate why diabetes is so hard to treat in children and teens, but it could be due to rapid growth and hormonal changes during puberty.

(MORE: What’s the Ideal BMI for Longevity?)

So what can be done? Obviously, the best treatment is prevention: “Don’t get diabetes in the first place,” researcher Dr. Phil Zeitler of the University of Colorado Denver told the Associated Press.

However, it will take a concerted national effort to help keep children from the increasing risk. In an editorial accompanying the study, Dr. David Allen of the department of pediatrics at the University of Wisconsin School of Medicine and Public Health, in Madison, writes:

Fifty years ago, children did not avoid obesity by making healthy choices; they simply lived in an environment that provided fewer calories and included more physical activity for all. Until a healthier “eat less, move more” environment is created for today’s children, lifestyle interventions like that in the…study will fail.

The stark message from the…study is that, tomorrow and beyond, public-policy approaches â€" sufficient economic incentives to produce and purchase healthy foods and to build safe environments that require physical movement â€" and not simply the prescription of more and better pills will be necessary to stem the epidemic of type 2 diabetes and its associated morbidity.

(MORE: Can a Formula Company Really Promote Breast-Feeding and Fight Child Obesity?)

In terms of immediate treatment, when the usual drugs fail, daily insulin shots may be needed. The researchers note that adding Avandia to metformin is not recommended for children or teens because the drug has been linked to an increased risk of heart attack and stroke in adults, and the U.S. Food and Drug Administration has severely restricted its use. Other oral medications for diabetes haven’t been studied or approved for use in children.

“A single pill or single approach is not going to get the job done,” study author Dr. Mitchell Geffner of the Children’s Hospital Los Angeles told the AP.

As America's waistline expands, costs soar - Reuters

A regular sized wheelchair (L) is pictured alongside an oversized one in the children's and women's maternity ward at the University of Alabama Hospital in Birmingham, Alabama, April 26, 2012. OBESITY/ REUTERS/Marvin Gentry

1 of 5. A regular sized wheelchair (L) is pictured alongside an oversized one in the children's and women's maternity ward at the University of Alabama Hospital in Birmingham, Alabama, April 26, 2012. OBESITY/

Credit: Reuters/Marvin Gentry

NEW YORK | Mon Apr 30, 2012 10:46am EDT

NEW YORK (Reuters) - U.S. hospitals are ripping out wall-mounted toilets and replacing them with floor models to better support obese patients. The Federal Transit Administration wants buses to be tested for the impact of heavier riders on steering and braking. Cars are burning nearly a billion gallons of gasoline more a year than if passengers weighed what they did in 1960.

The nation's rising rate of obesity has been well-chronicled. But businesses, governments and individuals are only now coming to grips with the costs of those extra pounds, many of which are even greater than believed only a few years ago: The additional medical spending due to obesity is double previous estimates and exceeds even those of smoking, a new study shows.

Many of those costs have dollar signs in front of them, such as the higher health insurance premiums everyone pays to cover those extra medical costs. Other changes, often cost-neutral, are coming to the built environment in the form of wider seats in public places from sports stadiums to bus stops.

The startling economic costs of obesity, often borne by the non-obese, could become the epidemic's second-hand smoke. Only when scientists discovered that nonsmokers were developing lung cancer and other diseases from breathing smoke-filled air did policymakers get serious about fighting the habit, in particular by establishing nonsmoking zones. The costs that smoking added to Medicaid also spurred action. Now, as economists put a price tag on sky-high body mass indexes (BMIs), policymakers as well as the private sector are mobilizing to find solutions to the obesity epidemic.

"As committee chairmen, Cabinet secretaries, the head of Medicare and health officials see these really high costs, they are more interested in knowing, 'what policy knob can I turn to stop this hemorrhage?'" said Michael O'Grady of the National Opinion Research Center, co-author of a new report for the Campaign to End Obesity, which brings together representatives from business, academia and the public health community to work with policymakers on the issue.

The U.S. health care reform law of 2010 allows employers to charge obese workers 30 percent to 50 percent more for health insurance if they decline to participate in a qualified wellness program. The law also includes carrots and celery sticks, so to speak, to persuade Medicare and Medicaid enrollees to see a primary care physician about losing weight, and funds community demonstration programs for weight loss.

Such measures do not sit well with all obese Americans. Advocacy groups formed to "end size discrimination" argue that it is possible to be healthy "at every size," taking issue with the findings that obesity necessarily comes with added medical costs.

The reason for denominating the costs of obesity in dollars is not to stigmatize plus-size Americans even further. Rather, the goal is to allow public health officials as well as employers to break out their calculators and see whether programs to prevent or reverse obesity are worth it.

LOST PRODUCTIVITY

The percentage of Americans who are obese (with a BMI of 30 or higher) has tripled since 1960, to 34 percent, while the incidence of extreme or "morbid" obesity (BMI above 40) has risen sixfold, to 6 percent. The percentage of overweight Americans (BMI of 25 to 29.9) has held steady: It was 34 percent in 2008 and 32 percent in 1961. What seems to have happened is that for every healthy-weight person who "graduated" into overweight, an overweight person graduated into obesity.

Because obesity raises the risk of a host of medical conditions, from heart disease to chronic pain, the obese are absent from work more often than people of healthy weight. The most obese men take 5.9 more sick days a year; the most obese women, 9.4 days more. Obesity-related absenteeism costs employers as much as $6.4 billion a year, health economists led by Eric Finkelstein of Duke University calculated.

Even when poor health doesn't keep obese workers home, it can cut into productivity, as they grapple with pain or shortness of breath or other obstacles to working all-out. Such obesity-related "presenteeism," said Finkelstein, is also expensive. The very obese lose one month of productive work per year, costing employers an average of $3,792 per very obese male worker and $3,037 per female. Total annual cost of presenteeism due to obesity: $30 billion.

Decreased productivity can reduce wages, as employers penalize less productive workers. Obesity hits workers' pocketbooks indirectly, too: Numerous studies have shown that the obese are less likely to be hired and promoted than their svelte peers are. Women in particular bear the brunt of that, earning about 11 percent less than women of healthy weight, health economist John Cawley of Cornell University found. At the average weekly U.S. wage of $669 in 2010, that's a $76 weekly obesity tax.

MORE DOCTORS, MORE PILLS

The medical costs of obesity have long been the focus of health economists. A just-published analysis finds that it raises those costs more than thought.

Obese men rack up an additional $1,152 a year in medical spending, especially for hospitalizations and prescription drugs, Cawley and Chad Meyerhoefer of Lehigh University reported in January in the Journal of Health Economics. Obese women account for an extra $3,613 a year. Using data from 9,852 men (average BMI: 28) and 13,837 women (average BMI: 27) ages 20 to 64, among whom 28 percent were obese, the researchers found even higher costs among the uninsured: annual medical spending for an obese person was $3,271 compared with $512 for the non-obese.

Nationally, that comes to $190 billion a year in additional medical spending as a result of obesity, calculated Cawley, or 20.6 percent of U.S. health care expenditures.

That is double recent estimates, reflecting more precise methodology. The new analysis corrected for people's tendency to low-ball their weight, for instance, and compared obesity with non-obesity (healthy weight and overweight) rather than just to healthy weight. Because the merely overweight do not incur many additional medical costs, grouping the overweight with the obese underestimates the costs of obesity.

Contrary to the media's idealization of slimness, medical spending for men is about the same for BMIs of 26 to 35. For women, the uptick starts at a BMI of 25. In men more than women, high BMIs can reflect extra muscle as well as fat, so it is possible to be healthy even with an overweight BMI. "A man with a BMI of 28 might be very fit," said Cawley. "Where healthcare costs really take off is in the morbidly obese."

Those extra medical costs are partly born by the non-obese, in the form of higher taxes to support Medicaid and higher health insurance premiums. Obese women raise such "third party" expenditures $3,220 a year each; obese men, $967 a year, Cawley and Meyerhoefer found.

One recent surprise is the discovery that the costs of obesity exceed those of smoking. In a paper published in March, scientists at the Mayo Clinic toted up the exact medical costs of 30,529 Mayo employees, adult dependents, and retirees over several years.

"Smoking added about 20 percent a year to medical costs," said Mayo's James Naessens. "Obesity was similar, but morbid obesity increased those costs by 50 percent a year. There really is an economic justification for employers to offer programs to help the very obese lose weight."

LIVING LARGE, BUT NOT DYING YOUNG

For years researchers suspected that the higher medical costs of obesity might be offset by the possibility that the obese would die young, and thus never rack up spending for nursing homes, Alzheimer's care, and other pricey items.

That's what happens to smokers. While they do incur higher medical costs than nonsmokers in any given year, their lifetime drain on public and private dollars is less because they die sooner. "Smokers die early enough that they save Social Security, private pensions, and Medicare" trillions of dollars, said Duke's Finkelstein. "But mortality isn't that much higher among the obese."

Beta blockers for heart disease, diabetes drugs, and other treatments are keeping the obese alive longer, with the result that they incur astronomically high medical expenses in old age just like their slimmer peers.

Some costs of obesity reflect basic physics. It requires twice as much energy to move 250 pounds than 125 pounds. As a result, a vehicle burns more gasoline carrying heavier passengers than lighter ones.

"Growing obesity rates increase fuel consumption," said engineer Sheldon Jacobson of the University of Illinois. How much? An additional 938 million gallons of gasoline each year due to overweight and obesity in the United States, or 0.8 percent, he calculated. That's $4 billion extra.

Not all the changes spurred by the prevalence of obesity come with a price tag. Train cars New Jersey Transit ordered from Bombardier have seats 2.2 inches wider than current cars, at 19.75 inches, said spokesman John Durso, giving everyone a more comfortable commute. (There will also be more seats per car because the new ones are double-deckers.)

The built environment generally is changing to accommodate larger Americans. New York's commuter trains are considering new cars with seats able to hold 400 pounds. Blue Bird is widening the front doors on its school buses so wider kids can fit. And at both the new Yankee Stadium and Citi Field, home of the New York Mets, seats are wider than their predecessors by 1 to 2 inches.

The new performance testing proposed by transit officials for buses, assuming an average passenger weight of 175 instead of 150 pounds, arise from concerns that heavier passengers might pose a safety threat. If too much weight is behind the rear axle, a bus can lose steering. And every additional pound increases a moving vehicle's momentum, requiring more force to stop and thereby putting greater demands on brakes. Manufacturers have told the FTA the proposal will require them to upgrade several components.

Hospitals, too, are adapting to larger patients. The University of Alabama at Birmingham's hospital, the nation's fourth largest, has widened doors, replaced wall-mounted toilets with floor models able to hold 250 pounds or more, and bought plus-size wheelchairs (twice the price of regulars) as well as mini-cranes to hoist obese patients out of bed.

The additional spending due to obesity doesn't fall into a black hole, of course. It contributes to overall economic activity and thus to gross domestic product. But not all spending is created equal.

"Yes, a heart attack will generate economic activity, since the surgeon and hospital get paid, but not in a good way," said Murray Ross, vice president of Kaiser Permanente's Institute for Health Policy. "If we avoided that heart attack we could have put the money to better use, such as in education or investments in clean energy."

The books on obesity remain open. The latest entry: An obese man is 64 percent less likely to be arrested for a crime than a healthy man. Researchers have yet to run the numbers on what that might save.

(Editing by Michele Gershberg and Prudence Crowther)


Teen Impulsiveness Has Different Sources in ADHD, Substance Use - U.S. News & World Report

By Jenifer Goodwin
HealthDay Reporter

SUNDAY, April 29 (HealthDay News) -- Teens with attention-deficit/hyperactivity disorder (ADHD) and teens who start using cigarettes, drugs or alcohol tend to share at least one personality trait: impulsiveness, experts say.

But a new brain-imaging study of nearly 1,900 14-year-olds finds that the brain networks associated with impulsivity in teens with ADHD are different compared to those who use drugs or alcohol.

What that finding suggests is that multiple underlying mechanisms drive impulsivity -- in other words, the impulsivity that leads kids to blow off their homework and the impulsiveness that drives kids to take a drag off a joint aren't the same, neurologically speaking.

"The behavior of the two groups might look the same, but it's driven by different brain networks," said lead study author Robert Whelan, a postdoctoral research fellow at the University of Vermont.

Moreover, the findings, published in the April 29 online issue of Nature Neuroscience, could suggest that the brain is primed to push some teens -- but not others -- toward substance abuse.

ADHD is a neurobehavioral disorder marked by excessive levels of activity, inattention and impulsiveness beyond what's normal for a child's age.

People with ADHD are at higher risk of substance abuse and alcoholism. The explanation was thought to lie in the lack of self-control or inability to curb impulses that are part of the disorder, Whelan said.

But the brain-imaging study suggests that from a neurological standpoint, ADHD and substance use may not be nearly as closely tied as previously believed, Whelan said.

In the study, researchers used data from an ongoing study of European teens who underwent brain imagining tests every two years starting at age 14. The youths were asked about symptoms of ADHD and if they had tried alcohol, cigarettes or other drugs.

While having their brains scanned, the students took a test used to measure self-control, or inhibition: Participants were told to press a button when they saw a right or a left arrow flash on a screen, but not to press the button when the arrow pointed up.

The kids with ADHD and those who had tried various substances didn't perform any worse on the test of self-control than other kids. However, researchers did find distinct patterns of brain activity in ADHD and in kids who'd tried alcohol, cigarettes or drugs while taking the test.

Among the kids who had tried alcohol, cigarettes or other drugs (mostly marijuana), scans showed different patterns of brain activity in the right inferior frontal gyrus and in the orbital frontal cortex compared to teens who had abstained. Prior research has found the inferior frontal gyrus is involved with inhibition. For example, people with head injuries that damaged that area of the brain have problems with inhibition, Whelan said, while the orbital frontal cortex has been implicated in drug use.

Even teens who reported having only tried a drink or two by age 14 showed a different pattern of activity in the orbital frontal cortex, suggesting the brain differences aren't caused by the substances, but are already present and play a role in what drives certain teens to experiment with alcohol and others to abstain, Whelan said.

In the teens who had symptoms of ADHD, different networks lit up during the self-control test. Kids with ADHD symptoms showed differences in the bilateral frontal lobe and the basal ganglia.

"The fact that we found there were different networks lends credence to the argument that ADHD and substance abuse are not so tightly coupled," Whelan said.

Dr. Lukshmi Puttanniah, director of child and adolescent psychiatry at Lenox Hill Hospital in New York City, said the study strongly suggests that impulsiveness can have many underlying explanations.

"It's adding to a body of knowledge that the fundamental thing underlying both ADHD and substance use is difficulty controlling impulses," Puttanniah said. "Some people thought that whatever neurobiological pathway that underlies it is common between ADHD and substance abuse. But what this study shows is the neurobiological pathways underlying the impulsivity of ADHD and substance use disorders are actually distinct."

Double-drug diabetes treatment disappoints in kids - Chicago Tribune

NEW YORK (Reuters Health) - In a large new trial looking at ways to slow the progression of type 2 diabetes in children and teens, the addition of a second drug to the mainstay treatment metformin was only marginally more effective at controlling blood sugar than metformin alone.

Within a year, on average, half of kids on metformin and some 40 percent taking both metformin and rosiglitazone (Avandia) ended up having to resort to insulin injections to control their blood sugar, researchers reported Sunday at the annual meeting of the Pediatric Academic Societies in Boston and in the New England Journal of Medicine online.

"The results of the study were discouraging," said Dr. David Allen from the University of Wisconsin School of Medicine and Public Health in an NEJM editorial. "These data imply that most youth with type 2 diabetes will require multiple oral agents or insulin therapy within a very few years after diagnosis."

All 699 children included in the study had been diagnosed with type 2 diabetes two years or less before enrollment, so the rapid advance of about half to needing insulin marks an early start to a potential lifetime of complications and side effects â€" from the diabetes itself and the medications used to treat the disease.

Type 2 diabetes, the form usually associated with obesity, was once considered an "adult" disease, but is showing up in more and more teenagers, paralleling a rise in childhood obesity. And the condition is harder to treat in kids, experts say.

Type 2 diabetes "progresses more rapidly" in youth, according to Dr. Phil Zeitler from the University of Colorado, Denver, who worked on the new study.

He and his colleagues were surprised at how quickly many of the youngsters needed to switch from oral medications to taking daily insulin shots, Zeitler told Reuters Health.

Also, Zeitler said, the teens in the study appeared to have complications, including infections and hospitalization, more often than adults do.

All the children in the study were overweight or obese, and ranged in age from 10 to 17 years old.

Youngsters with diabetes are a difficult population to work with, Zeitler noted. Many of them don't take their medications as instructed. And in the first place, to get type 2 diabetes before adulthood, "the toxicity of your lifestyle must be pretty severe," Zeitler said.

That's why all of the kids in the study got at least "basic lifestyle counseling," he emphasized â€" for example, advice to stop drinking sugared sodas, eat less fast food, watch their diet in other healthy ways, take stairs instead of elevators and generally get more exercise.

Study enrollment began in July 2004 and follow-up continued through February 2011. All the kids in the study were taking metformin, a well-established diabetes drug, and a third were assigned to take the newer drug Avandia as well.

Another third of the kids were assigned a very intensive "lifestyle intervention," that involved more assignments for kids to complete, more interaction with counselors, and close involvement of at least one parent, in addition to taking metformin.

The kids' treatments were deemed failures if blood sugar and other signs pointed to their diabetes not being under control for a period of six months or more.

In the end, 52 percent of kids on metformin alone "failed" treatment, along with 39 percent of kids on metformin and Avandia and 47 percent of kids on metformin and lifestyle changes.

The median time it took for blood sugar control to be lost was just under a year.

The added benefit of Avandia was limited to girls, for reasons that are unclear, the researchers reported.

Also for unknown reasons, they noted, metformin alone was less effective for non-Hispanic black participants than other kids.

Surprisingly, kids on the combination of metformin and Avandia gained the most weight during the study, despite their slightly better rate of diabetes control. Kids in the lifestyle intervention group gained the least weight.

Zeitler pointed out, "You can see in the data a suggestion that there might be groups of children who respond to the very intensive intervention. Our challenge now is: Can we identify the kids who are going to respond to a lifestyle intervention and (just one oral diabetes medicine)?"

Conversely, he continued, the challenge is also to recognize from the start the kids for whom the intensive lifestyle intervention is "going to be ineffective and not worth the time and money."

Overall, 19 percent of the participants developed serious adverse effects such as severe hypoglycemia, diabetic ketoacidosis and lactic acidosis.

The rate in the treatment groups was 18 percent in the metformin-only group, 15 percent in the double-drug group and 25 percent in the group that received the very intensive lifestyle intervention, but the rate of specific problems, such as hyperglycemia, were not significantly higher between the groups.

Finding the reasons for the differences between these groups of children in their response to treatments will require further research, Zeitler and his colleagues conclude in their report.

In his editorial, Allen says it's critical to remember that the patients in this study are "youth immersed from a young age in a sedentary, calorie-laden environment that may well have induced and now aggravates their type 2 diabetes."

"Fifty years ago," the editorial continues, "children did not avoid obesity by making healthy choices; they simply lived in an environment that provided fewer calories and included more physical activity for all. Until a healthier 'eat less, move more' environment is created for today's children, lifestyle interventions like that in the ...study will fail."

SOURCE: http://bit.ly/InSsRZ New England Journal of Medicine, online April 29, 2012.

Number of painkiller-addicted newborns soars - USA TODAY

The number of babies born addicted to the class of drugs that includes prescription painkillers has nearly tripled in the past decade, according to the first national study of its kind.

  • Babies born in withdrawal are often born small and are at a higher risk of death than other infants, according to the study.

    Sean Gallup, Getty Images

    Babies born in withdrawal are often born small and are at a higher risk of death than other infants, according to the study.

Sean Gallup, Getty Images

Babies born in withdrawal are often born small and are at a higher risk of death than other infants, according to the study.

About 3.4 of every 1,000 infants born in a hospital in 2009 suffered from a type of drug withdrawal commonly seen in the babies of pregnant women who abuse narcotic pain medications, the study says. It's published today in The Journal of the American Medical Association.

That's about 13,539 infants a year, or one drug-addicted baby born every hour, says the study's lead author, Stephen Patrick, a fellow in neonatal-perinatal medicine at the University of Michigan.

Treating drug-addicted newborns, most of whom are covered by the publicly financed Medicaid program, cost $720 million in 2009, the study says.

The country has an obligation to help these newborns, who "have made no choices around drug abuse and addiction" and are "the most vulnerable and the most blameless" members of society, says Marie Hayes, psychology professor at the University of Maine, who was not involved in the study.

Unlike in the 1980s and 1990s, when hospitals saw a surge in babies born addicted to crack cocaine, many newborns today arrive hooked on powerful prescription painkillers, such as Vicodin and Oxycontin, Patrick says. The type of withdrawal Patrick studied, called neonatal abstinence syndrome, produces different symptoms from those caused by cocaine. The syndrome also can be caused by illegal opiates, such as heroin, Patrick says, but this surge in addicted babies probably is explained by the national "epidemic" of prescription drug abuse.

The number of pregnant women who used or abused narcotic painkillers increased fivefold from 2000 to 2009, his study found. These mothers now account for 5.6 out of 1,000 hospital births a year, the study found. The findings also were presented at the annual meeting of the Pediatric Academic Societies in Boston.

"The prevalence of drug use among pregnant women hasn't changed since the early 2000s," says Andreea Creanga, a researcher with the Centers for Disease Control and Prevention, noting about 4.5% of pregnant women use illegal drugs. "But the types of drugs that women are using is changing."

The CDC has flagged prescription painkiller abuse as a major health threat, noting that these drugs now cause more overdose deaths than heroin and cocaine combined. And the problem is getting worse. The death rate from overdoses in 2007 â€" 12 deaths per 100,000 people â€" was roughly three times higher than in 1991, a CDC report in November showed. Most of that increase came from prescription drugs.

Many of these mothers tell their doctors they didn't realize prescription painkillers could harm their babies, perhaps because the drugs are technically legal, says Mark Hudak, a spokesman for the American Academy of Pediatrics who wrote the group's 2012 clinical report on newborn withdrawal. Other mothers are addicted when they become pregnant and simply unable to quit, he says.

Babies born in withdrawal are often born small and are at a higher risk of death than other infants, Patrick says. Doctors try to relieve the pain of surviving babies by treating them with methadone, a narcotic painkiller commonly used to treat heroin addicts. Doctors reduce the dose slowly over weeks to avoid causing sudden withdrawal symptoms, Patrick says.

Doctors and nurses sometimes can tell which babies are going through withdrawal from the hallway, without even seeing them, simply by hearing their cries, Patrick says. These babies are irritable and hard to console, with stiff, rigid muscles that won't relax. They have tremors, seizures and breathing problems. They have trouble feeding and resist taking a bottle. They throw up frequently and produce watery diarrhea. "It's like a colicky baby times 10," Patrick says.

Sometimes, these babies are exposed to multiple drugs in the womb, from tobacco and alcohol to antidepressants and other psychiatric drugs, says Howard Heiman, associate chief of the neonatal intensive care unit at Cohen Children's Medical Center of New York. Researchers need to find better ways to treat drug-addicted mothers and to identify and treat addicted babies as early as possible.

Some states have been hit harder than others, Hayes says, particularly those with high rates of rural poverty, such as Maine and Kentucky. In Florida, the number of babies with withdrawal syndrome soared from 354 in 2006 to 1,374 in 2010, according to the Florida Agency for Health Care Administration. In response, Florida's attorney general has convened a task force to address the problem of drug-addicted newborns.

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