Uterus transplants, from mother to daughter, lift hope - Philadelphia Inquirer

STOCKHOLM, Sweden - Two Swedish women are hoping to get pregnant after undergoing what doctors are calling the world's first mother-to-daughter uterus transplants.

Specialists at the University of Goteborg said they performed the surgery over the weekend without complications but added that they won't consider it successful unless the women give birth to healthy children.

"That's the best proof," said Michael Olausson, one of the surgeons.

One of the unidentified women had her uterus removed many years ago because of cervical cancer, while the other was born without a womb. Both are in their 30s.

They will undergo a year of observation before doctors attempt to help them get pregnant via in vitro fertilization, in which embryos created with eggs from their own ovaries will be implanted in their wombs.

Researchers around the world have been looking for ways to transplant wombs so that women who have lost a uterus to cancer or other diseases can become pregnant.

Fertility experts hailed the Swedish transplants as a significant step but stressed it remains to be seen whether they will result in successful pregnancies.

Even if the approach works, it is unclear how many women will choose such an option, given the risks and the extreme nature of the operation compared with, say, using a surrogate mother.

Turkish doctors last year said they performed the first successful uterus transplant, giving a womb from a deceased donor to a young woman. Olausson said that woman was doing fine, but he did not know if she has started fertility treatment.

In 2000, doctors in Saudi Arabia transplanted a uterus from a live donor, but it had to be removed three months later because of a blood clot.

For a year, doctors will monitor how the two patients respond to the antirejection drugs needed to stop their immune systems from attacking the donated wombs.

After a maximum of two pregnancies, the wombs will be removed so the women can stop taking the drugs, which can have side effects such as high blood pressure and diabetes and which may also raise the risk of some types of cancer.

James Grifo, an infertility expert at New York University, questioned how a fetus would be affected by the immune-suppressing drugs.

"Some people will always be willing to take the risk, but there are issues that need to be addressed before you expose a fetus to these medicines," he said. Grifo and colleagues at NYU abandoned a uterus-transplant program "because some issues seemed insurmountable."

In Sweden, Olausson said antirejection drugs had not proved harmful to fetuses when the mother has undergone other organ transplants.